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Female gang members generally would be the ones to negotiate the stolen checks. The blocking vehicle, usually a rental car, was used to distract tellers in the first drivethrough lane, the lane closest to the teller window. Often a sports utility vehicle would be used as its larger size provided greater blocking of the second vehicle and suspect in the outside lane. The blocking vehicle s occupants would try to engage the teller in conversation to further distract the teller s attention from being too focused on the other transaction taking place in the outside lane. The female defendants made sure to wear wigs to match the hair color of the photo on the stolen identification documents. The defendants also did account takeovers where they impersonated the true account holder either in person or by telephone. They would change the home address on the victim s account and also use stolen credit cards at merchants in the area. The scheme began in Florida in 2004 and moved to Virginia, where it continued from September 2006 into 2007. Losses in Florida were in the millions of dollars. Losses to financial institutions in the Eastern District of Virginia exceeded $350,000. On November 1, 2006, 20 defendants were indicted in the Southern District of Florida on various charges of conspiracy to commit bank fraud, aggravated identity theft, and identity theft. In April 2007, the leader of the conspiracy was sentenced to nine years in prison. Other members of the gang received jail sentences between one and three years with lesser-involved participants receiving probation. In December 2007, six members of the gang pleaded guilty in the Eastern District of Virginia to charges of conspiracy to commit bank fraud and aggravated identity theft.

However, differences in context between the natural function of a given AMP as part of innate immunity compared to its repeated application in higher concentrations have raised a number of important issues regarding toxicity and appearance of unexpected secondary activities Regarding their potential toxicity, as part of innate immunity, AMP function is controlled by several processes including expression levels, storage in granules, and synthesis as inactive pro-peptides requiring enzymatic activation for biological activity (as in the case of cathelicidin) (Jenssen et al 2006) These features underline the importance of preservation of a minimum basal concentration as well as the potential activation of undesired routes at high concentrations AMP in vivo activity is optimized not only for concentration but also for the site of action.

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In this sense, combination with other effector molecules with overlapping antimicrobial functions can yield additive and synergistic effects or even the manifestation of secondary activities (Li et al 2000; Boman 2003) An example of this strategy is the targeted killing designed by Eckert et al (2006) In this work, the AMP novispirin G10 was synthetically fused to a linker sequence followed by the targeting peptide KH (KKHRKHRKHRKH) to display increased bacterial activity and speci city against Pseudomonas mendocina 62 Experience in the Clinical Application of AMPs As the problem of emergence of bacterial resistance to current antibiotic drugs continues to grow, there has been considerable interest in the development of alternative anti-infectious therapies Given the origin of the AMPs and their mode of action, development of resistance to AMPs was believed to be unlikely.

Nevertheless, various pathogens have developed resistance through different mechanisms, such as the modi cation of the cell wall or expression of proteases (Barak et al 2005) Even with this potential limitation, to date, several AMP-based compounds have been developed and entered into clinical trials The results from these trials are somehow discouraging due to the limited success, and none of the AMP-based compounds has succeeded in getting Food and Drug Administration (FDA) approval for clinical use (Table 83) 63 New Strategies and Potential for Pharmacological Exploitation of AMPs To date, most advances in the eld of AMP optimization have been limited by the expense of production However, the fast development of high-throughput approaches together with the design of solid cell.

Converts an image in grayscale. Reverses the hue, saturation, and luminance of an image. Creates the illusion that an object is illuminated by one or more light sources. Sets all the transparent pixels to the specified color and converts the nontransparent pixels to the background color.

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